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Trends Cell Biol. 2019 Jun;29(6):514-530. doi: 10.1016/j.tcb.2019.01.006. Epub 2019 Feb 19.

Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration.

Author information

1
Molecular Neuroregeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK; Institute for Bioengineering of Catalonia-Barcelona Institute of Science and Technology, Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain; CIBERNED, Barcelona, Spain; These authors made an equal contribution.
2
School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK; These authors made an equal contribution.
3
Molecular Neuroregeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK; These authors made an equal contribution.
4
School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK. Electronic address: ajay.shah@kcl.ac.uk.
5
Molecular Neuroregeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address: s.di-giovanni@imperial.ac.uk.

Abstract

Adult postmitotic mammalian cells, including neurons and cardiomyocytes, have a limited capacity to regenerate after injury. Therefore, an understanding of the molecular mechanisms underlying their regenerative ability is critical to advance tissue repair therapies. Recent studies highlight how redox signalling via paracrine cell-to-cell communication may act as a central mechanism coupling tissue injury with regeneration. Post-injury redox paracrine signalling can act by diffusion to nearby cells, through mitochondria or within extracellular vesicles, affecting specific intracellular targets such as kinases, phosphatases, and transcription factors, which in turn trigger a regenerative response. Here, we review redox paracrine signalling mechanisms in postmitotic tissue regeneration and discuss current challenges and future directions.

PMID:
30795898
DOI:
10.1016/j.tcb.2019.01.006

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