CRISPR-Cas Systems Reduced to a Minimum

Cristóbal Almendros; Sebastian N Kieper; Stan J J Brouns

doi:10.1016/j.molcel.2019.02.005

CRISPR-Cas Systems Reduced to a Minimum

Mol Cell. 2019 Feb 21;73(4):641-642. doi: 10.1016/j.molcel.2019.02.005.

Authors

Cristóbal Almendros¹, Sebastian N Kieper¹, Stan J J Brouns²

Affiliations

¹ Kavli Institute of Nanoscience, Department of Bionanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands.
² Kavli Institute of Nanoscience, Department of Bionanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands. Electronic address: stanbrouns@gmail.com.

PMID: 30794791
DOI: 10.1016/j.molcel.2019.02.005

Abstract

In two recent studies in Molecular Cell, Wright et al. (2019) report complete spacer integration by a Cas1 mini-integrase and Edraki et al. (2019) describe accurate genome editing by a small Cas9 ortholog with less stringent PAM requirements.

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MeSH terms

CRISPR-Cas Systems*
Gene Editing*