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Int J Mol Sci. 2019 Feb 19;20(4). pii: E896. doi: 10.3390/ijms20040896.

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.

Author information

1
Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany. mhalder@ukaachen.de.
2
Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands. p.petsophonsakul@maastrichtuniversity.nl.
3
Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands. a.akbulut@maastrichtuniversity.nl.
4
Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands. a.pavlic@maastrichtuniversity.nl.
5
NattoPharma ASA, 0283 Oslo, Norway. frode@nattopharma.com.
6
NattoPharma ASA, 0283 Oslo, Norway. eric.anderson@nattopharma.com.
7
International Science & Health Foundation, 30-134 Krakow, Poland. katarzyna.maresz@nutricon.eu.
8
Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany. rkramann@ukaachen.de.
9
Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany. l.schurgers@maastrichtuniversity.nl.
10
Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands. l.schurgers@maastrichtuniversity.nl.

Abstract

Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K can be present in various isoforms, distinguishable by two main structures, namely, phylloquinone (K1) and menaquinones (K2). The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor for the enzyme gamma-glutamylcarboxylase, encompassing both hepatic and extrahepatic activity. Only carboxylated proteins are active and promote a health profile like hemostasis. Furthermore, vitamin K2 in the form of MK-7 has been shown to be a bioactive compound in regulating osteoporosis, atherosclerosis, cancer and inflammatory diseases without risk of negative side effects or overdosing. This review is the first to highlight differences between isoforms vitamin K1 and K2 by means of source, function, and extrahepatic activity.

KEYWORDS:

vascular calcification; vitamin K dependent proteins; vitamin K1; vitamin K2

PMID:
30791399
PMCID:
PMC6413124
DOI:
10.3390/ijms20040896
[Indexed for MEDLINE]
Free PMC Article

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