Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Christian Haass; Michael Willem

doi:10.1016/j.neuron.2019.01.058

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Neuron. 2019 Feb 20;101(4):557-559. doi: 10.1016/j.neuron.2019.01.058.

Authors

Christian Haass¹, Michael Willem²

Affiliations

¹ Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-University Munich, 81377 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address: christian.haass@mail03.med.uni-muenchen.de.
² Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.

PMID: 30790537
DOI: 10.1016/j.neuron.2019.01.058

Abstract

The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABA_BR1a.

Publication types

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MeSH terms

Amyloid beta-Peptides
Amyloid beta-Protein Precursor*
Biological Transport
Ligands
Synaptic Transmission*

Substances

Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Ligands