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Pediatr Allergy Immunol. 2019 May;30(3):335-340. doi: 10.1111/pai.13018. Epub 2019 Feb 21.

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial.

Author information

1
Hans Christian Andersen Hospital for Children and Adolescents, Odense University Hospital, Odense C, Denmark.
2
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark.
3
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense C, Denmark.

Abstract

BACKGROUND:

Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization.

METHODS:

In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo-starting prior to attending day care. The intervention period was 6 months, and the parents answered web-based questionnaires on allergic symptoms and doctor's diagnosed allergic disease monthly. IgE was measured at baseline and follow-up.

RESULTS:

A total of 290 participants were randomized: 144 in the probiotic group and 146 in the placebo group. Mean age at intervention start was 10.1 months. At follow-up (mean age 16.1 months), the incidence of eczema was 4.2% in the probiotic group and 11.5% in the placebo group (P = 0.036). The incidence of asthma and conjunctivitis did not differ between groups, and no children presented with rhinitis. Sensitization was equal in the two groups at intervention start (7.5% and 9.5%, respectively), and two children in each group were sensitized during the intervention.

CONCLUSIONS:

We observed a significantly lower incidence of eczema in the probiotic group compared to the placebo group. The probiotics were administered in late infancy-prior to attending day care-suggesting a broader window of opportunity using probiotics in the prevention of eczema. The incidence of asthma, rhinitis, conjunctivitis, and sensitization did not differ.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02180581.

KEYWORDS:

Lactobacillus rhamnosus ; Bifidobacterium animalis subsp. lactis; RCT; allergic diseases; allergy; atopy; sensitization

PMID:
30790361
DOI:
10.1111/pai.13018
[Indexed for MEDLINE]

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