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Org Lett. 2019 Mar 1;21(5):1444-1448. doi: 10.1021/acs.orglett.9b00193. Epub 2019 Feb 21.

Fungal Biosurfactants from Mortierella alpina.

Author information

1
Pharmaceutical Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute , Friedrich-Schiller-University Jena , Winzerlaer Strasse 2 , 07745 Jena , Germany.
2
Pharmaceutical Technology and Biopharmacy , Friedrich-Schiller-University Jena , Lessingstrasse 8 , 07743 Jena , Germany.

Abstract

The zygomycete Mortierella alpina is a well-known producer of polyunsaturated fatty acids in the food industry. Two series of its secondary metabolites are reported: Malpinins, a family of amphiphilic acetylated hexapeptides, were chemically characterized and serve as natural emulsifiers during lipid secretion. Additionally, hydrophobic cyclopentapeptides, malpibaldins, were structurally elucidated by NMR experiments, and their absolute stereochemistry was elucidated through chemical derivatization and synthesis. This work highlights lower fungi as a novel reservoir for natural products.

PMID:
30789272
DOI:
10.1021/acs.orglett.9b00193
[Indexed for MEDLINE]

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