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Emerg Infect Dis. 2019 Mar;25(3):555-558. doi: 10.3201/eid2503.181220.

Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.

Abstract

A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008-2014) revealed an outbreak of TUR genotype strains in a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizophrenia likely fueled acquisition of additional resistance and bacterial fitness-related mutations over 2 decades.

KEYWORDS:

MDR TB; Serbia; antimicrobial resistance; bacteria; multidrug-resistant; outbreak; transmission; tuberculosis; tuberculosis and other mycobacteria; whole-genome sequencing

PMID:
30789133
PMCID:
PMC6390760
DOI:
10.3201/eid2503.181220
[Indexed for MEDLINE]
Free PMC Article

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