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Emerg Infect Dis. 2019 Mar;25(3):473-481. doi: 10.3201/eid2503.180336.

Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.

Abstract

Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.

KEYWORDS:

Mycobacterium avium; Mycobacterium avium water; Nontuberculous mycobacteria; Pennsylvania; Philadelphia; United States; VNTR; bacteria; genome sequencing; household biofilms; tuberculosis and other mycobacteria

PMID:
30789130
PMCID:
PMC6390762
DOI:
10.3201/eid2503.180336
[Indexed for MEDLINE]
Free PMC Article

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