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Emerg Infect Dis. 2019 Mar;25(3):538-546. doi: 10.3201/eid2503.181370.

Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.

Abstract

To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012-2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions.

KEYWORDS:

MDR TB; Mycobacterium tuberculosis; Tunisia; WGS; XDR TB; antimicrobial resistance; bacteria; cgMLST; drug resistance marker; extensively drug-resistant; multidrug-resistant; tuberculosis and other mycobacteria; whole-genome sequencing

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