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Br J Haematol. 2019 May;185(4):708-712. doi: 10.1111/bjh.15810. Epub 2019 Feb 20.

Expression of GNAZ, encoding the Gαz protein, predicts survival in mantle cell lymphoma.

Author information

1
Proteomics and Biomarkers, The Broad Institute of MIT and Harvard, Boston, Cambridge, MA, USA.
2
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
3
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
4
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
5
Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Abstract

Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non-malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0·014) and lymphocytosis (Mann-Whitney, P = 0·011). We show that GNAZ translates to Gαz protein - a signalling molecule within the G-protein coupled receptor network. Our findings suggest that GNAZ/Gαz contribute to the MCL pathobiology.

KEYWORDS:

G-protein coupled receptors; G-proteins; lymphocytosis; mantle cell lymphoma; prognosis

PMID:
30788840
DOI:
10.1111/bjh.15810

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