Format

Send to

Choose Destination
Bull Exp Biol Med. 2019 Feb;166(4):466-468. doi: 10.1007/s10517-019-04373-8. Epub 2019 Feb 20.

Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation.

Author information

1
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
2
Institute of Biochemistry and Genetics, Ufa Federal Research Center of Russian Academy of Sciences, Ufa, Republic of Bashkortostan, Russia.
3
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. juvv73@gmail.com.

Abstract

Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity. The possible mitogenic action of Noopept was estimated by its effect on cell proliferation. Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study. These data suggest that Noopept does not stimulate cell growth.

KEYWORDS:

Ki-67; Noopept; Pro-Gly substituted dipeptides; cell cycle; proliferation

PMID:
30788746
DOI:
10.1007/s10517-019-04373-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center