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Am J Transl Res. 2019 Jan 15;11(1):269-279. eCollection 2019.

Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients.

Zhang C1,2,3, Yang Y2, Chen R4, Wei Y5, Feng Y1,2, Zheng W6,7, Liao H4, Zhang Z1,2,8.

Author information

1
School of Medicine, Shanghai Jiao Tong University Shanghai 200025, China.
2
Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University Shanghai 200080, China.
3
Department of Obstetrics and Gynecology, Songjiang Maternal and Child Health Hospital Shanghai 201600, China.
4
Department of Cervical Diseases, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University Shanghai 200040, China.
5
Institute of Bioscience and Biotechnology, Yangzhou University Yangzhou, China.
6
Department of Pathology, University of Texas Southwestern Medical Center Dallas, TX 75390, USA.
7
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center Dallas, TX 75390, USA.
8
Department of Obstetrics and Gynecology, Shanghai First People's Hospital Baoshan Branch, Shanghai 201900, China.

Abstract

Gestational diabetemellitus (GDM) is a condition whereby a mother's glucose tolerance is impaired with onset or first recognition during pregnancy which is not either type 1 or type 2 diabetes mellitus. Oxidative stress plays an essential role in diabetes, however, whether it also includes in GDM has not been fully clarified. Therefore, we investigated the changes of oxidative stress biomarkers and their relationship with pregnancy outcomes in patients with GDM. The serum and placenta were collected for absorbance-based assay and immunohistochemistry assay (IHC). The patients' clinical information was collected and the pregnancy outcome was tracked. It was found that elder age is a risk factor to result in GDM. Moreover, GDM patients showed poor clinical factors or outcomes including higher prepregnancy weight and BMI value, premature delivery, higher rates of cesarean delivery, macrosomia, premature rupture of fetal membranes (PROM). Increasing serum MDA level and decline GSH and SOD levels were observed in GDM patients. Meanwhile, HO-1, Nrf2 and NQO1 overexpressed in GDM placental tissues. In the GDM group, MDA level was negatively associated with prepregnancy weight, while, SOD level was positively correlated with neonatal birth weight. We found an intensive relationship between SOD content and preterm birth in the GDM group. There is no significant difference between the level of MDA/GSH and neonatal birth weight as well as preterm birth. MDA, GSH and SOD levels were not associated with an increased risk of cesarean delivery or PROM. This study indicates aberrant expression of oxidative stress related proteins affects the pregnancy outcome of GDM patients.

KEYWORDS:

GDM; GSH; MDA; SOD; oxidative stress

PMID:
30787985
PMCID:
PMC6357329

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