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Oman J Ophthalmol. 2019 Jan-Apr;12(1):31-36. doi: 10.4103/ojo.OJO_224_2017.

Ganglion cell complex loss in patients with type 1 diabetes: A 36-month retrospective study.

Author information

1
Department of Ophthalmology and Visual Science, Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
2
Department of Ophthalmology and Visual Science, State University of New York College of Optometry, New York, USA.

Abstract

BACKGROUND:

To analyze changes over a 3-year period in ganglion cell complex (GCC) thickness in individuals with type 1 diabetes mellitus (T1DM) using spectral-domain optical coherence tomography (Optovue, Fremont, CA, USA).

METHODS:

Thirty-seven individuals from "Friends for Life Conference" with T1DM and a 3-year history of GCC thickness measurements were included in the study. Data analysis using SPSS 22 and Excel StatPlus was completed to note the subgroups that had a significant change.

RESULTS:

Significant decreases were noted in the following subgroups with slope in parenthesis. Overall: GCC superior thickness OD (-0.48)Male: GCC thickness OD (-0.86), GCC superior thickness OD (-0.735)Body mass index (BMI) 25.0-29.9: GCC thickness OD (-0.48), GCC superior thickness OS (-0.915), GCC inferior thickness OD (-0.43)Ages 10-20 years: GCC superior thickness OD (-0.635)Duration of diabetes 10-20 years: GCC thickness OD (-1.055), GCC superior thickness OD (-0.99).

CONCLUSION:

GCC loss was noted in individuals who were males, those with BMIs of 25.0-29.9, and those who had diabetes for 10-20 years. Ganglion cell loss was also noted before the presence of any diabetic retinopathy, suggesting onset of neuronal loss before any vasculature changes.

KEYWORDS:

Diabetic retinopathy; ganglion cell complex; neuronal cell loss; optical coherence tomography

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