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Nat Commun. 2019 Feb 20;10(1):880. doi: 10.1038/s41467-019-08469-7.

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.

Author information

1
Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
2
Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
3
Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
4
Department of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA.
5
Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
6
Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, USA.
7
Center for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD, 20892, USA.
8
Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA.
9
Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
10
Immunology Service, Universidade Federal da Bahia, Salvador, 401110170, Brazil.
11
Department of Medicine, Northwestern University, Chicago, IL, 60611, USA.
12
Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
13
Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
14
Universidade Federal da Bahia, Salvador, 401110170, Brazil.
15
Department of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA.
16
National Human Genome Center, Howard University College of Medicine, Washington, DC, 20059, USA.
17
Caribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica.
18
Departamento de Biorregulacao, Universidade Federal da Bahia, Salvador, 401110170, Brazil.
19
Department of Medicine, Einstein Medical Center, Philadelphia, PA, 19141, USA.
20
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
21
Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France.
22
Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
23
Facultad de Medicina, Universidad Católica de Honduras, San Pedro Sula, 21102, Honduras.
24
Universidad Tecnológica Centroamericana (UNITEC), Facultad de Ciencias Médicas, Tegucigalpa, Honduras.
25
Department of Pediatrics, Northwestern University, Chicago, IL, 60611, USA.
26
Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados.
27
Centro de Neumologia y Alergias, San Pedro Sula, 21102, Honduras.
28
Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
29
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
30
Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador, 40296-710, Brazil.
31
Department of Medicine and Center for Global Health, University of Chicago, Chicago, IL, 60637, USA.
32
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, 30322, USA.
33
Faculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital, Bridgetown, St. Michael, BB11000, Barbados.
34
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
35
Departments of Biomedical Engineering and Biostatistics, Johns Hopkins University, Baltimore, MD, 21205, USA.
36
Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
37
Center for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI, 48202, USA.
38
Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA.
39
Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA.
40
Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA. kathleen.barnes@ucdenver.edu.

Abstract

Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.

PMID:
30787307
PMCID:
PMC6382865
DOI:
10.1038/s41467-019-08469-7
[Indexed for MEDLINE]
Free PMC Article

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