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Curr Opin Neurobiol. 2019 Aug;57:102-109. doi: 10.1016/j.conb.2019.01.012. Epub 2019 Feb 19.

Septin functions during neuro-development, a yeast perspective.

Author information

1
University of Lyon, University of Lyon 1 Claude Bernard Lyon1, NeuroMyoGene Institute, CNRS UMR5310, INSERM U1217, 8 Avenue Rockefeller, Lyon F-69008, France.
2
University of Lyon, University of Lyon 1 Claude Bernard Lyon1, NeuroMyoGene Institute, CNRS UMR5310, INSERM U1217, 8 Avenue Rockefeller, Lyon F-69008, France. Electronic address: valerie.castellani@univ-lyon1.fr.

Abstract

Septins, discovered almost half a century ago in yeast, have prominent contributions in a broad range of morphological and functional processes from yeast to human. Septins now emerge as key players of neurodevelopment and more specifically of the mechanisms driving the complex morphological differentiation and compartmentalization of neurons that are fundamental to their function. We review here recent advances in Septin-mediated processes of neuron differentiation, which enlighten similarities and differences between neuron and yeast polarity programs.

PMID:
30784977
DOI:
10.1016/j.conb.2019.01.012
[Indexed for MEDLINE]

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