Osteoporosis and the Critically Ill Patient

Neil R Orford; Julie A Pasco; Mark A Kotowicz

doi:10.1016/j.ccc.2018.11.006

Osteoporosis and the Critically Ill Patient

Crit Care Clin. 2019 Apr;35(2):301-313. doi: 10.1016/j.ccc.2018.11.006. Epub 2019 Jan 28.

Authors

Neil R Orford¹, Julie A Pasco², Mark A Kotowicz³

Affiliations

¹ University Hospital Geelong, Barwon Health, Bellerine St, Geelong, VIC 3220, Australia; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine (DEPM), Monash University, 553 St Kilda Rd, Melbourne, VIC 3004, Australia; School of Medicine, Deakin University, 75 Pigdons Rd, Geelong, VIC 3216, Australia. Electronic address: neilo@barwonhealth.org.au.
² University Hospital Geelong, Barwon Health, Bellerine St, Geelong, VIC 3220, Australia; School of Medicine, Deakin University, 75 Pigdons Rd, Geelong, VIC 3216, Australia; Department of Epidemiology and Preventive Medicine (DEPM), Monash University, Wellington Rd, Clayton, VIC 3800, Australia; Department of Medicine, Melbourne Medical School-Western Campus, The University of Melbourne, McKechnie St, St Albans, VIC 3021, Australia.
³ University Hospital Geelong, Barwon Health, Bellerine St, Geelong, VIC 3220, Australia; School of Medicine, Deakin University, 75 Pigdons Rd, Geelong, VIC 3216, Australia; Department of Medicine, Melbourne Medical School-Western Campus, The University of Melbourne, McKechnie St, St Albans, VIC 3021, Australia.

PMID: 30784611
DOI: 10.1016/j.ccc.2018.11.006

Abstract

Improved survival after critical illness has led to recognition of impaired recovery following critical illness as a major public health problem. A consistent association between critical illness and accelerated bone loss has been described, including changes in bone turnover markers, bone mineral density, and fragility fracture rate. An association between accelerated bone turnover and increased mortality after critical illness is probable. Assessment of the effect of antifracture agents on fracture rate and mortality in the high-risk population of postmenopausal women with prolonged ventilation is warranted.

Keywords: Bone loss; Bone mineral density; Critical illness; Fracture; Long-term outcomes; Osteoporosis.

Publication types

Review

MeSH terms

Adult
Aged
Aged, 80 and over
Bone Density / drug effects*
Bone Density Conservation Agents / therapeutic use*
Critical Illness / therapy*
Diphosphonates / therapeutic use*
Female
Fractures, Bone / drug therapy*
Humans
Male
Middle Aged
Osteoporosis / drug therapy*
Osteoporosis / etiology*
Risk Assessment
Risk Factors

Substances

Bone Density Conservation Agents
Diphosphonates