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Amino Acids. 2019 Apr;51(4):691-704. doi: 10.1007/s00726-019-02706-5. Epub 2019 Feb 19.

The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial.

Author information

1
Institute of Cellular Medicine, Faculty of Medical Sciences, School of Biomedicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. tom.clifford@newcastle.ac.uk.
2
School of Biomedical Sciences, Newcastle University, Newcastle upon Tyne, UK.
3
Norwich Medical School, University of East Anglia, Norfolk and Norwich University Hospital Norfolk, Norwich, UK.
4
Rousselot BVBA, Ghent, Belgium.
5
Institute of Cellular Medicine, Faculty of Medical Sciences, School of Biomedicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Abstract

This study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day-1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. Maximal isometric voluntary contractions, countermovement jumps (CMJ), muscle soreness (200 mm visual analogue scale), pressure pain threshold, Brief Assessment of Mood Adapted (BAM +) and a range of blood markers associated with muscle damage, inflammation and bone turnover C-terminal telopeptide of type 1 collagen (β-CTX) and N-terminal propeptides of type 1 pro-collagen (P1NP) were measured before supplementation (baseline; BL), pre, post, 1.5, 24 and 48 h post-exercise. Muscle soreness was not significantly different in CP and CON (P = 0.071) but a large effect size was evident at 48 h post-exercise, indicative of lower soreness in the CP group (90.42 ± 45.33 mm vs. CON 125.67 ± 36.50 mm; ES = 2.64). CMJ height recovered quicker with CP than CON at 48 h (P = 0.050; CP 89.96 ± 12.85 vs. CON 78.67 ± 14.41% of baseline values; ES = 0.55). There were no statistically significant effects for the other dependent variables (P > 0.05). β-CTX and P1NP were unaffected by CP supplementation (P > 0.05). In conclusion, CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis.

KEYWORDS:

Bone turnover; Collagen; Exercise recovery; Hydrolyzed collagen; Inflammation; Muscle soreness

PMID:
30783776
DOI:
10.1007/s00726-019-02706-5

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