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Phys Rev E. 2019 Jan;99(1-1):012401. doi: 10.1103/PhysRevE.99.012401.

Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes.

Author information

1
Department of Physics, Clark University, Worcester, Massachusetts 01610, USA.
2
Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
3
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
4
Chan Zuckerberg Biohub, San Francisco, California 943158, USA.
5
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA.

Abstract

We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.

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