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Arch Dermatol Res. 2019 Apr;311(3):183-191. doi: 10.1007/s00403-019-01892-2. Epub 2019 Feb 18.

Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.

Author information

1
ToutVert Co. Ltd, Osaka, Japan.
2
Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan.
3
Quines Square Dermatological Clinic, Kanagawa, Japan.
4
Ebisu Skin Research Center, Inforward Co. LTD, Tokyo, Japan.
5
Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan. imokawag@dream.ocn.ne.jp.
6
Research Institute for Biological Functions, Chubu University, Aichi, Japan. imokawag@dream.ocn.ne.jp.

Abstract

Little is known about the anti-pigmenting effects of whitening agents on solar lentigos (SLs), which comprise ~ 60% of hyperpigmented facial lesions of Asian subjects. Lotions with or without 6% L-ascorbate-2-phosphate trisodium salt (APS) [test lotion (TL) and placebo lotion (PL), respectively] were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs on both sides of their faces. Pigmentation scores were evaluated using a photo-scale and the skin colors were assessed using a color difference meter and a mexameter for SLs and the non-lesional surrounding skin (NLS). Although the pigmentation scores were not significantly different between the TL and PL-treated SLs after 24 weeks, the L values of TL-treated SLs and NLS increased significantly with a significantly higher △L value in SLs than in NLS. In contrast, the L values of PL-treated SLs and NLS remained unchanged after the treatment. The number of subjects with > 2.0 △L was 7 of 27 (TL) and 0 of 27 (PL) in SLs and 3 of 27 (TL) and 0 of 27 (PS) in NLS. In contrast, the melanin index in TL-treated SLs and NLS significantly decreased with a significantly higher △melanin index in SLs than in NLS. Similarly, the melanin index of PL-treated SLs and NLS were significantly decreased with a significantly higher △melanin index in SLs than in NLS. These findings strongly indicate that APS has a weak but significant anti-pigmenting effect on SLs and a significant whitening effect even on normally pigmented healthy skin.

KEYWORDS:

Double-blind half-face study; L value; L-Ascorbate-2-phosphate trisodium salt; Melanin index; Pigmentation; Solar lentigo

PMID:
30778667
DOI:
10.1007/s00403-019-01892-2
[Indexed for MEDLINE]

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