Mitochondrial Dysfunction in Neural Injury

Xiu-Yun Zhao; Mei-Hong Lu; De-Juan Yuan; De-En Xu; Pei-Pei Yao; Wen-Li Ji; Hong Chen; Wen-Long Liu; Chen-Xiao Yan; Yi-Yuan Xia; Shao Li; Jin Tao; Quan-Hong Ma

doi:10.3389/fnins.2019.00030

Mitochondrial Dysfunction in Neural Injury

Front Neurosci. 2019 Feb 4:13:30. doi: 10.3389/fnins.2019.00030. eCollection 2019.

Authors

Xiu-Yun Zhao^{1

2}, Mei-Hong Lu^{1

2}, De-Juan Yuan^{1

3}, De-En Xu⁴, Pei-Pei Yao^{1

2}, Wen-Li Ji^{1

2}, Hong Chen^{1

2}, Wen-Long Liu^{1

2}, Chen-Xiao Yan^{1

2}, Yi-Yuan Xia^{1

2}, Shao Li³, Jin Tao^{1

5}, Quan-Hong Ma¹

Affiliations

¹ Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, China.
² Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
³ Department of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, China.
⁴ Wuxi No. 2 People's Hospital, Wuxi, China.
⁵ Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou, China.

Abstract

Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.

Keywords: mitochondria; mitochondrial dysfunction; neural injury; neurodegeneration; neurological disorders.

Publication types

Review