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Sci Rep. 2019 Feb 18;9(1):2204. doi: 10.1038/s41598-019-39700-6.

The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls.

Author information

1
Department of Obstetrics and Gynecology, Koc University Faculty of Medicine, Istanbul, Turkey. barisata@ku.edu.tr.
2
Department of Obstetrics and Gynecology, Koc University Hospital, Istanbul, Turkey.
3
Área de Genómica y Salud, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública), Valencia, Spain.
4
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey.
5
Institute for Integrative Systems Biology, Universitat de València, Valencia, Spain.
6
CIBER en Epidemiología y Salud Pública (CIBEResp), Madrid, Spain.
7
Department of Obstetrics and Gynecology, Koc University Faculty of Medicine, Istanbul, Turkey.

Abstract

Dysbiosis in the genital tract or gut microbiome can be associated with endometriosis. We sampled vaginal, cervical and gut microbiota from 14 women with histology proven stage 3/4 endometriosis and 14 healthy controls. The V3 and V4 regions of the 16S rRNA gene were amplified following the 16S Metagenomic Sequencing Library Preparation. Despite overall similar vaginal, cervical and intestinal microbiota composition between stage 3/4 endometriosis group and controls, we observed differences at genus level. The complete absence of Atopobium in the vaginal and cervical microbiota of the stage 3/4 endometriosis group was noteworthy. In the cervical microbiota, Gardnerella, Streptococcus, Escherichia, Shigella, and Ureoplasma, all of which contain potentially pathogenic species, were increased in stage 3/4 endometriosis. More women in the stage 3/4 endometriosis group had Shigella/Escherichia dominant stool microbiome. Further studies can clarify whether the association is causal, and whether dysbiosis leads to endometriosis or endometriosis leads to dysbiosis.

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