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Indian J Ophthalmol. 2019 Mar;67(3):344-349. doi: 10.4103/ijo.IJO_613_18.

Confounding sizing in posterior chamber phakic lens selection due to white-to-white measurement bias.

Author information

Department of Ophthalmology (Qvision), Vithas Virgen del Mar Hospital, 04120; Department of Ophthalmology, Torrecárdenas Hospital Complex, 04009, Almería, Spain.
Department of Ophthalmology (Qvision), Vithas Virgen del Mar Hospital, 04120, Almería, Spain.
Department of Optics, Pharmacology and Anatomy, University of Alicante; Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, Alicante, Spain.



To assess the agreement in the white-to-white (WTW) measurement with two different devices, the reproducibility and the probability of confusing sizing (PCS) in selecting a different implantable collamer lens (ICL).

Study Design:

Retrospective observational case series.


Images of 192 eyes were captured with both devices. The WTW was measured automatically (OA) and manually (OM) with the Orbscan and Keratograph (KA and KM) by one examiner who repeated a total of four measures. A second examiner conducted a single manual measure for each device over the same image. The ICL sizing was computed for each measure of WTW and the PCS was calculated as the percentage of cases for which the confronted or repeated measure resulted in a different size of the ICL. The critical WTWs with highest PCS were identified.


KM overestimated the WTW versus OM in 0.13 ± 0.18 mm (P < 0.001) but not in the automated method comparison, 0.01 ± 0.19 mm (P = 0.58). Inter-examiner reproducibility (R) was higher with OM than with KM, and the intra-examiner R decreased with the average of two measures in both cases. The PCS was higher with the increase of mean differences, the limits of agreement (LoAs), and R. WTWs from 11.1 to 11.2 mm, 11.6 to 11.7 mm, and 12.3 to 12.4 mm resulted in higher PCS.


The mean difference is not enough to apply conversions between devices and the LoAs and R should be considered. Special attention should be taken for WTWs with higher PCS.


Agreement; posterior chamber phakic intraocular lens; reproducibility; sizing; white-to-white

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