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Reprod Biol. 2019 Mar;19(1):1-5. doi: 10.1016/j.repbio.2019.02.003. Epub 2019 Feb 15.

The role of progesterone elevation in IVF.

Author information

1
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Belgium. Electronic address: panagiotisdrakopoulos@hotmail.com.
2
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; University of Genoa, Academic Unit of Obstetrics and Gynecology, IRCCS AOU San Martino, Italy.
3
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Centre for Reproductive Medicine, Clínica Alemana, Santiago, Chile.
4
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Belgium.
5
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
6
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Belgium; University of Zagreb-School of Medicine, Department of Obstetrics and Gynecology, Zagreb, Croatia.
7
Division of Obstetrics and Gynecology, University Hospital of Geneva, Geneva, Switzerland.
8
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Belgium; IVI-RMA, Lisbon, Portugal.

Abstract

Elevation of progesterone during the late follicular phase of stimulated in-vitro fertilization cycles is a frequent event, which negatively impacts the outcome. Over the years evidence has demonstrated a direct relationship between late-follicular elevated progesterone and endometrial receptivity. In this regard, elective cryopreservation of all good quality embryos and transfer in a subsequent frozen/thawed cycle is the most common strategy adopted by clinicians in case of elevated progesterone. Nonetheless, recent evidence suggests that elective cryopreservation might not entirely resolve the reduced pregnancy outcomes associated with the elevation of progesterone, considering that the increase may affect not only implantation, but also embryo quality.

KEYWORDS:

Embryo quality; Endometrial receptivity; Implantation; In vitro fertilization; Progesterone elevation

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