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Trends Cogn Sci. 2019 Apr;23(4):318-333. doi: 10.1016/j.tics.2019.01.006. Epub 2019 Feb 16.

Exercise and Hippocampal Memory Systems.

Author information

1
Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA. Electronic address: michelle-voss@uiowa.edu.
2
Laboratory of Neurogenesis and Neuroplasticity, Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico.
3
Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA.
4
Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.

Abstract

No medications prevent or reverse age-related cognitive decline. Physical activity (PA) enhances memory in rodents, but findings are mixed in human studies. As a result, exercise guidelines specific for brain health are absent. Here, we re-examine results from human studies, and suggest the use of more sensitive tasks to evaluate PA effects on age-related changes in the hippocampus, such as relational memory and mnemonic discrimination. We discuss recent advances from rodent and human studies into the underlying mechanisms at both the central and peripheral levels, including neurotrophins and myokines that could contribute to improved memory. Finally, we suggest guidelines for future research to help expedite well-founded PA recommendations for the public.

KEYWORDS:

aging; growth factors; hippocampus; myokines; neurogenesis; pattern separation; physical activity; relational memory

PMID:
30777641
PMCID:
PMC6422697
[Available on 2020-04-01]
DOI:
10.1016/j.tics.2019.01.006

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