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J Alzheimers Dis. 2019;68(2):531-535. doi: 10.3233/JAD-181054.

Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward.

Author information

1
Neuroimaging and Neurospectroscopy Laboratory (NINS), National Brain Research Centre, Gurgaon, India.
2
Florey Institute of Neuroscience and Mental Health, University of Melbourne Medical school campus, Melbourne, Australia.
3
Department of Neurology, All Indian Institute of Medical Science, New Delhi, India.
4
Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.
5
Department of Biological and Medical Psychology, University of Bergen, Norway.
6
NORMENT Center of Excellence, Haukeland University Hospital, Norway.

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be important player in AD pathology. Glutathione (GSH) is a major antioxidant, and it is already known that GSH is depleted significantly in the hippocampal regions in mild cognitive impairment (MCI) and AD patients compared to healthy old subjects. Hence there is a serious discussion to improve the brain GSH level by supplementation. This editorial highlights the need for GSH supplementation for the cognitive enhancement in MCI and AD.

PMID:
30776003
DOI:
10.3233/JAD-181054

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