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Int J Prev Med. 2019 Jan 15;10:7. doi: 10.4103/ijpvm.IJPVM_252_17. eCollection 2019.

Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims.

Author information

1
Department of Nutrition, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, I.R. Iran.
2
Department of Laboratory Technology, Paramedical Faculty, Bushehr University of Medical Sciences, Bushehr, I.R. Iran.
3
Department of Nutrition, Student Research Committee, Bushehr University of Medical Sciences, Bushehr, I.R. Iran.

Abstract

Background:

Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before-after study was to investigate the effects of fasting in Ramadan on IGF-1 and IL-2 levels in individuals.

Methods:

In all, 34 men age 16-64 years were selected out of the overall number of individuals who were ready for fasting entirely throughout Ramadan. A sample of blood was drawn from the contributors before and after Ramadan, and plasma IGF-1, IL-2, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined. To identify differences between the initial and final values of test results of the study for plasma IGF-1, IL-2, and lipid parameters, we used paired sample T-test.

Results:

Paired sample T-test illustrated a significant decrease in IGF-1 and IL-2 levels after Ramadan fasting compared to before Ramadan. The concentration of TG, cholesterol, and LDL-C levels underwent significant decreases over the period of the study. HDL-C levels did not change significantly during the study. A significant decrease in weight, waist circumferences, calorie, carbohydrate, and fat intake were observed in participants during Ramadan fasting.

Conclusions:

It is concluded that fasting in Ramadan independent of anthropometric measures attenuates inflammation and is beneficiary to health.

KEYWORDS:

Fasting; insulin-like growth factor-1; lipids

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