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Med Sci (Paris). 2019 Feb;35(2):132-137. doi: 10.1051/medsci/2019002. Epub 2019 Feb 18.

[VEGF-C and lymphatic vessels: a double-edged sword in tumor development and metastasis].

[Article in French]

Author information

1
Université Côte d'Azur, Institut de recherche sur le cancer et le vieillissement de Nice, CNRS UMR 7284 ; Inserm U1081, Centre Antoine Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
2
Université Côte d'Azur, Institut de recherche sur le cancer et le vieillissement de Nice, CNRS UMR 7284 ; Inserm U1081, Centre Antoine Lacassagne, 33, avenue de Valombrose, 06189 Nice, France - Centre scientifique de Monaco, Département de biologie médicale, 8, quai Antoine Ier, MC-98000 Monaco, Principauté de Monaco.

Abstract

The lymphatic system is made up of vessels that drain interstitial fluids throughout the body. The circulation of the lymph (liquid in the lymphatic system) in the lymphatic vessels is unidirectional: tissues to the lymph nodes and then to the veins. Ganglia are mechanical filters but also immune barriers that can block the progression of certain pathogens as well as cancer cells. However, most studies on the lymphatic system and cancer highlight the role of the lymphatic network in metastatic dissemination as tumor cells use this network to reach other organs. However, recent studies describe a beneficial role of the lymphatic system and of the vascular endothelial growth factor C (VEGF-C) which is one of the main factors responsible for the development of lymphatic vessels in cancer. In this review, we will illustrate this ambivalent and emerging role of VEGF-C and the lymphatic system in cancer aggressiveness.

PMID:
30774080
DOI:
10.1051/medsci/2019002

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