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Biosci Biotechnol Biochem. 2019 May;83(5):914-922. doi: 10.1080/09168451.2019.1580135. Epub 2019 Feb 17.

Mulberry juice freeze-dried powder attenuates the disease severity by the maintaining of colon mucosa in mice with DSS-induced acute colitis.

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a Laboratory of Animal Physiology, Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.


This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions.


DSS-induced acute colitis; Mulberry; NLRP6 inflammasome; goblet cell; microbiota

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