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Immunopharmacol Immunotoxicol. 2019 Feb 18:1-6. doi: 10.1080/08923973.2018.1558235. [Epub ahead of print]

Tachykinin upregulation in atopic dermatitis.

Author information

1
a Department of Medicine Solna, Dermatology and Venereology Unit , Karolinska Institutet , Stockholm , Sweden.
2
b Department of Dermatology , Karolinska University Hospital Solna , Stockholm , Sweden.
3
c Diagnostiskt Centrum Hud , Stockholm , Sweden.
4
d Department of Woman and Child Health, Pediatric Endocrinology Unit , Astrid Lindgren Children's Hospital , Stockholm , Sweden.
5
e Department of Molecular Medicine and Surgery , Karolinska Institutet , Stockholm , Sweden.
6
f College of Dentistry , King Faisal University , Al-Ahsa , Kingdom of Saudi Arabia.
7
g Centre for Psychiatry Research, Department of Clinical Neuroscience , Karolinska Institutet , Stockholm , Sweden.

Abstract

CONTEXT:

Atopic dermatitis (AD) is a chronic, inflammatory, itching skin disorder, which may worsen due to stress, depression and anxiety. Tachykinins may be involved in inflammation signaling as well as they may have a role in stress, depression and anxiety.

OBJECTIVE:

This study aimed to measure the expression of tachykinin markers, in the skin of patients with AD, and the correlation of these tachykinins with clinical and psychodemographic parameters.

MATERIALS AND METHODS:

Twenty-eight adult patients with AD were investigated regarding tachykinin expression in skin biopsies, using an immunohistochemical technique. The patients were characterized with clinical and psychodemographic parameters.

RESULTS:

The number of substance P and neurokinin (NK)A positive nerve fibers, as well as NKA positive mononuclear dermal cells, was increased in lesional compared to non-lesional skin. Interestingly, the depression score and the number of dermal NK-1 receptor (R) positive cells in lesional as well as in non-lesional skin showed a correlation.

CONCLUSION:

These findings indicate an upregulation of the tachykinergic system in the inflamed skin of AD.

KEYWORDS:

Anxiety; atopic dermatitis; depression; inflammation; tachykinins

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