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Cell Calcium. 2019 May;79:1-10. doi: 10.1016/j.ceca.2019.01.005. Epub 2019 Feb 8.

ORAI channels in cellular remodeling of cardiorespiratory disease.

Author information

1
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
2
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States. Electronic address: mtrebak@psu.edu.

Abstract

Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca2+) signaling and specifically ORAI Ca2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.

KEYWORDS:

ARC; Asthma; Atherosclerosis; COPD; CRAC; Hypertension; ORAI; Pulmonary hypertension; Remodeling; Restenosis; SOCE; STIM

PMID:
30772685
PMCID:
PMC6461505
[Available on 2020-05-01]
DOI:
10.1016/j.ceca.2019.01.005

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