Send to

Choose Destination
Mult Scler Relat Disord. 2019 May;30:154-162. doi: 10.1016/j.msard.2019.01.051. Epub 2019 Jan 30.

Validity of a multi-domain computerized cognitive assessment battery for patients with multiple sclerosis.

Author information

Department of Neurology & Multiple Sclerosis Center, Lady Davis Carmel Medical Center, Haifa, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:
Washington Neuropsychology Research Group, Fairfax, VA, USA; Department of Neurology, Georgetown University, Washington DC, USA.
Department of Clinical Research, NeuroTrax Corporation, Modiin, Israel; Joseph Sagol Neuroscience Center & Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Ramat Gan, Israel.
Washington Neuropsychology Research Group, Fairfax, VA, USA.
South Shore Neurologic Associates, 77 Medford Avenue, Patchogue, NY 11772, USA.
South Shore Neurologic Associates, 77 Medford Avenue, Patchogue, NY 11772, USA. Electronic address:



Computerized cognitive batteries may facilitate the integration of neuropsychological assessments into routine clinical care of patients with multiple sclerosis (PwMS).


To assess the construct and criterion validity of a computerized, multi-domain cognitive assessment battery (CAB, NeuroTrax) in MS.


81 PwMS and 15 healthy controls (HC) completed the CAB and a set of traditional neuropsychological tests recommended for MS on the same day. Principal component factor analysis was used to assess construct validity. For criterion validity, the gold standard definition of cognitive impairment was a score of ≥1.5SD below average on at least one cognitive domain, based upon traditional test normative data. Receiver operating characteristic (ROC) analysis was used to examine the ability of the CAB to discriminate cognitively impaired PwMS.


Traditional and computerized tests of memory, processing speed, visuospatial and executive function converged by factor analysis. Computerized tests detected cognitive impairment with 85% sensitivity and 70% specificity. PwMS classified as impaired on only the computerized battery had significantly prolonged response times and a higher rate of unemployment compared with PwMS classified as unimpaired on both batteries. Poor executive function was more likely to be revealed by the CAB.


The specific computerized assessment battery evaluated is valid for cognitive screening of people with MS and may be more likely to detect prolonged response times and impaired executive function.


Cognitive function; Computerized cognitive assessment; Multiple sclerosis; Response time; Validity

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center