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Pharmacol Res. 2019 Apr;142:77-86. doi: 10.1016/j.phrs.2019.01.045. Epub 2019 Feb 14.

Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies.

Author information

1
Department of Health Sciences, "Magna Graecia" University of Catanzaro, 88100, Catanzaro, Italy.
2
Department of Health Sciences, "Magna Graecia" University of Catanzaro, 88100, Catanzaro, Italy. Electronic address: bulotta@unicz.it.

Abstract

Phenolic secoiridoids from olive, including oleocanthal, oleuropein and related derivatives, are bioactive natural products with documented anticancer activities, that have mainly been attributed to their antioxidant, anti-inflammatory and antiproliferative effects. This review summarizes the results of the preclinical studies on the natural secoiridoids of olive used as single agents or in combination with other chemotherapeutics against cancer cells. The molecular targets of their action are described. A critical analysis of the importance of the experimental studies in view of the possible use in humans is also discussed.

KEYWORDS:

Adjuvant; Cancer; Hydroxytyrosol; Hydroxytyrosol (CID: 82755); Oleacein (CID: 18684078); Oleocanthal; Oleocanthal (CID: 11652416); Oleuropein; Oleuropein (CID: 5281544); Oleuropein aglycone (CID: 56842347); Olive secoiridoids; Tyrosol (CID: 10393)

PMID:
30772463
DOI:
10.1016/j.phrs.2019.01.045

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