Format

Send to

Choose Destination
Braz J Infect Dis. 2019 Feb 14. pii: S1413-8670(18)30556-7. doi: 10.1016/j.bjid.2018.12.002. [Epub ahead of print]

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil.

Author information

1
Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Programa de Pós-Graduação em Medicina e Saúde, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.
2
Universidade Federal da Bahia, Programa de Pós-Graduação em Medicina e Saúde, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.
3
Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.
4
Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.
5
Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil; Universidade Federal da Bahia, Bahia, Departamento de Medicina, Salvador, BA, Brazil. Electronic address: crbrites@gmail.com.

Abstract

BACKGROUND:

Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.

OBJECTIVE:

To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT.

METHODS:

Two independent reviewers performed a systematic review on search engines PubMed, Europe PMC, Cochrane, Scientific Electronic Library Online (SciELO), and Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs), using the following key terms: "HIV infection", "HIV newborn", "HLA polymorphisms", "HLA-B", and "Mother to child transmission". All studies focusing on evaluation of HIV-1 MTCT, HIV infection evolution, and molecular analyses of HLA-B in children were selected.

RESULTS:

Nine studies fulfilled the inclusion criteria. Sixteen HLA-B alleles groups were associated with HIV-1 infection; seven of them (43.8%) were related to slow disease progression or reduced risk of MTCT, while six (37.5%) alleles groups were linked to a faster progression of HIV infection in children and to increased risk of MTCT. The available evidence suggest that HLA-B*57 group allele is associated with slow disease progression, while HLA-B*35 group allele is associated to increased risk of MTCT and rapid disease progression in infected children. The role of HLA-B*18, B*58 and B*44 are still controversial because they were associated to both, protection against MTCT, and to higher HIV replicative capacity, in different studies.

CONCLUSION:

HLA-B*57 group allele can be protective against MTCT while HLA-B*35 groups alleles are consistently associated with HIV-1 MTCT.

KEYWORDS:

“HIV”; “HLA-B”; “Mother to child transmission”

PMID:
30772367
DOI:
10.1016/j.bjid.2018.12.002
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center