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Clin Perinatol. 2019 Mar;46(1):51-64. doi: 10.1016/j.clp.2018.10.005. Epub 2018 Dec 20.

Influence of Growth Factors on the Development of Necrotizing Enterocolitis.

Author information

1
Department of Pediatric Surgery, Center for Perinatal Research, The Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
2
Department of Pediatric Surgery, Nationwide Children's Hospital, FB6135, 700 Children's Drive, Columbus, OH 43205, USA. Electronic address: Gail.Besner@NationwideChildrens.org.

Abstract

Growth factors have important roles in gastrointestinal tract development, maintenance, and response to injury. Various experiments have been used to demonstrate growth factor influence in multiple disease processes. These studies demonstrated enhancement of mucosal proliferation, intestinal motility, immune modulation, and many other beneficial effects. Select growth factors, including epidermal growth factor and heparin-binding epidermal growth factor like growth factor, demonstrate some beneficial effects in experimental and clinical intestinal injury demonstrated in necrotizing enterocolitis. The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.

KEYWORDS:

Growth factors; Intestinal injury; Necrotizing enterocolitis

PMID:
30771819
PMCID:
PMC6380490
[Available on 2020-03-01]
DOI:
10.1016/j.clp.2018.10.005

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