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Clin Perinatol. 2019 Mar;46(1):101-117. doi: 10.1016/j.clp.2018.09.006. Epub 2018 Dec 12.

Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia.

Author information

1
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, 3rd Floor, Atlanta, GA 30322, USA.
2
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA.
3
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, 3rd Floor, Atlanta, GA 30322, USA. Electronic address: rmpatel@emory.edu.

Abstract

This article summarizes available evidence on the relationship between red blood cell transfusion and anemia, and necrotizing enterocolitis (NEC). We review recent studies that highlight the uncertainty of the effect of red blood cell transfusion on NEC and the potential role of anemia. We also discuss potential pathophysiologic effects of both red blood cell transfusion and anemia and highlight strategies to prevent anemia and red blood cell transfusion. We also discuss ongoing randomized trials that are likely to provide important new evidence to guide red blood cell transfusion practices.

KEYWORDS:

Blood; Infant; Morbidity; Neonate; Oxygenation; Preterm

PMID:
30771812
PMCID:
PMC6383803
[Available on 2020-03-01]
DOI:
10.1016/j.clp.2018.09.006

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