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Nat Rev Immunol. 2019 Apr;19(4):205-217. doi: 10.1038/s41577-019-0131-x.

Cytokine-mediated communication: a quantitative appraisal of immune complexity.

Author information

1
Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. gregoire.altan-bonnet@nih.gov.
2
Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Abstract

Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Here, we discuss recent efforts in the field of systems immunology to bring about a quantitative understanding of cytokine-mediated communication between leukocytes and to provide novel insights into the orchestration of immune responses and inflammation.

PMID:
30770905
DOI:
10.1038/s41577-019-0131-x

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