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J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28325. [Epub ahead of print]

Berberine as a potential autophagy modulator.

Author information

1
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
2
Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, Shushtar, Khuzestan, Iran.
3
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
4
Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Abstract

Today, pharmacognosy is considered a valuable science in the prevention and treatment of diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Surprisingly, it shows antimicrobial, antiviral, antidiarrheal, antipyretic, and anti-inflammatory potential. Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms. In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine acts as an autophagy modulator to adjust physiologic and pathologic conditions and diminishes drug resistance in cancer therapy.

KEYWORDS:

autophagy; berberine; drug-resistant; pharmacognosy; programmed cell death

PMID:
30770555
DOI:
10.1002/jcp.28325

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