Send to

Choose Destination
Learn Mem. 2019 Feb 15;26(3):77-83. doi: 10.1101/lm.049072.118. Print 2019 Mar.

Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain.

Author information

Montréal Neurological Institute, Department of Neurology and Neurosurgery, 3801 Rue University, McGill University, Montréal, Québec H3A 2B4, Canada.
NSERC CREATE Neuroengineering Training Program, McGill University, Montréal, Québec H3A 2B4, Canada.
Contributed equally


Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent secretion of netrin-1 by neurons potentiates glutamatergic synapse function, and is critical for long-term potentiation, an experimental cellular model of learning and memory. Here, we assessed the impact of neuronal expression of netrin-1 in the adult brain on behavior using tests of learning and memory. We show that adult mice exhibit impaired spatial memory following conditional deletion of netrin-1 from glutamatergic neurons in the hippocampus and neocortex. Further, we provide evidence that mice with conditional deletion of netrin-1 do not display aberrant anxiety-like phenotypes and show a reduction in self-grooming behavior. These findings reveal a critical role for netrin-1 expressed by neurons in the regulation of spatial memory formation.

[Available on 2020-03-01]

Supplemental Content

Loading ...
Support Center