Format

Send to

Choose Destination
EMBO J. 2019 Mar 1;38(5). pii: e101633. doi: 10.15252/embj.2019101633. Epub 2019 Feb 15.

Ubiquitin-a beacon for all during quality control on the ribosome.

Author information

1
Department of Biology, Washington University in St. Louis, St. Louis, MO, USA.

Abstract

Ribosome stalling triggers no-go decay (NGD) and ribosome-associated quality control (RQC) pathways to rapidly degrade the aberrant mRNA and the incomplete nascent peptide, respectively. Two recent studies in yeast and mammalian systems reveal the importance of stalling-induced ribosomal protein ubiquitination by Hel2/ZNF598 for both NGD and RQC The studies also structurally explain how collided ribosomes generate a unique interface not present in monosomes, which can be recognized by Hel2/ZNF598 ubiquitin ligases.

PMID:
30770343
PMCID:
PMC6396152
[Available on 2020-03-01]
DOI:
10.15252/embj.2019101633

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center