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Eur J Surg Oncol. 2019 Jan 30. pii: S0748-7983(19)30249-5. doi: 10.1016/j.ejso.2019.01.223. [Epub ahead of print]

Pre- and post-operative antibiotics in conjunction with cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC) should be considered for pseudomyxoma peritonei (PMP) treatment.

Author information

1
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. Electronic address: douglas.merrell@usuhs.edu.
2
Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, 20742, USA. Electronic address: mcavoy@umd.edu.
3
Department of Surgical Oncology, Mercy Medical Center, Baltimore, MD, 21202, USA.
4
Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA.
5
Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
6
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
7
University of South Carolina School of Medicine, Columbia, SC, USA.
8
Department of Surgical Oncology, Mercy Medical Center, Baltimore, MD, 21202, USA. Electronic address: asardi@mdmercy.com.

Abstract

Pseudomyxoma peritonei (PMP) is a subtype of peritoneal carcinomatosis that is traditionally treated by cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC). A growing body of evidence suggests that microbes are associated with various tumor types and have been found in organs and cavities that were once considered sterile. Prior and ongoing research from our consortium of PMP researchers strongly suggests that bacteria are associated with PMP tumors. While the significance of this association is unclear, in our opinion, further research is warranted to understand whether these bacteria contribute to the development, maintenance and/or progression of PMP. Elucidation of a possible causal role for bacteria in PMP could suggest a benefit for supplementation of antibiotics to current treatment protocols.

KEYWORDS:

Antibiotics; Cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC); Helicobacter; Microbiota; Pseudomyxoma peritonei (PMP)

PMID:
30770164
DOI:
10.1016/j.ejso.2019.01.223

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