Format

Send to

Choose Destination
J Med Chem. 2019 Mar 14;62(5):2843-2848. doi: 10.1021/acs.jmedchem.9b00102. Epub 2019 Feb 21.

Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.

Author information

1
Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.
2
Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
3
Institute of Molecular Biotechnology, Austrian Academy of Sciences , Dr. Bohr Gasse 3 , AT-1030 Vienna , Austria.
4
Lead Discovery Center GmbH , Otto-Hahn-Strasse 15 , 44227 Dortmund , Germany.

Abstract

The protein kinase MKK7 is linked to neuronal development and the onset of cancer. The field, however, lacks high-quality functional probes that would allow for the dissection of its detailed functions. Against this background, we describe an effective covalent inhibitor of MKK7 based on the pyrazolopyrimidine scaffold.

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center