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Obesity (Silver Spring). 2019 Apr;27(4):542-550. doi: 10.1002/oby.22406. Epub 2019 Feb 14.

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial.

Author information

1
Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
2
Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois, USA.
3
Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.
4
Department of Nutrition, University of California, Davis, California, USA.

Abstract

OBJECTIVE:

This study investigated the effect of red raspberry intake on meal-induced postprandial metabolic responses in individuals who have overweight or obesity with prediabetes and insulin resistance (PreDM-IR), and in metabolically healthy individuals (Reference).

METHODS:

Thirty-two adults (PreDM-IR, n = 21; Reference, n = 11) were randomized to a controlled, three-arm, single-blinded, crossover trial. Participants were provided 0 g of frozen red raspberries (Control), 125 g of frozen red raspberries (RR-125) (~1 cup), or 250 g of frozen red raspberries (RR-250) (~2 cups), with a challenge breakfast meal (high carbohydrate/moderate fat) on three separate days. Multiple blood samples were collected up to 8 hours post breakfast with a final blood sample at 24 hours. A snack was provided at 6 hours.

RESULTS:

Breakfast containing RR-125 and RR-250 significantly reduced 2-hour insulin area under the curve, and RR-250 reduced peak insulin, peak glucose, and 2-hour glucose AUC compared with Control in the PreDM-IR group (P < 0.05). Postprandial triglycerides were significantly lower after RR-125 versus RR-250 (P = 0.01) but not different from Control (P > 0.05). No significant meal-related differences were observed for oxidative stress or inflammatory biomarkers.

CONCLUSIONS:

Our findings suggest that red raspberries aid in postmeal glycemic control in individuals with PreDM-IR, reducing glycemic burden with less insulin, which may be related to improved tissue insulin sensitivity.

PMID:
30767409
DOI:
10.1002/oby.22406

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