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Obesity (Silver Spring). 2019 Apr;27(4):542-550. doi: 10.1002/oby.22406. Epub 2019 Feb 14.

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial.

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Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois, USA.
Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.
Department of Nutrition, University of California, Davis, California, USA.



This study investigated the effect of red raspberry intake on meal-induced postprandial metabolic responses in individuals who have overweight or obesity with prediabetes and insulin resistance (PreDM-IR), and in metabolically healthy individuals (Reference).


Thirty-two adults (PreDM-IR, n = 21; Reference, n = 11) were randomized to a controlled, three-arm, single-blinded, crossover trial. Participants were provided 0 g of frozen red raspberries (Control), 125 g of frozen red raspberries (RR-125) (~1 cup), or 250 g of frozen red raspberries (RR-250) (~2 cups), with a challenge breakfast meal (high carbohydrate/moderate fat) on three separate days. Multiple blood samples were collected up to 8 hours post breakfast with a final blood sample at 24 hours. A snack was provided at 6 hours.


Breakfast containing RR-125 and RR-250 significantly reduced 2-hour insulin area under the curve, and RR-250 reduced peak insulin, peak glucose, and 2-hour glucose AUC compared with Control in the PreDM-IR group (P < 0.05). Postprandial triglycerides were significantly lower after RR-125 versus RR-250 (P = 0.01) but not different from Control (P > 0.05). No significant meal-related differences were observed for oxidative stress or inflammatory biomarkers.


Our findings suggest that red raspberries aid in postmeal glycemic control in individuals with PreDM-IR, reducing glycemic burden with less insulin, which may be related to improved tissue insulin sensitivity.


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