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South Asian J Cancer. 2019 Jan-Mar;8(1):69-71. doi: 10.4103/sajc.sajc_229_18.

Multimodality treatment of head-and-neck soft-tissue sarcomas and short-term outcomes: Analysis from sarcoma medical oncology clinic.

Author information

1
Department of Medical Oncology, IRCH, AIIMS, New Delhi, India.
2
Department of Radiation Oncology, Lok Nayak Hospital, New Delhi, India.
3
Department of Surgical Oncology, IRCH, AIIMS, New Delhi, India.
4
Department of Pathology, AIIMS, New Delhi, India.
5
Department of Radiodiagnosis, IRCH, AIIMS, New Delhi, India.
6
Department of Radiation Oncology, IRCH, AIIMS, New Delhi, India.
7
Department of Oncoanaesthesia, IRCH, AIIMS, New Delhi, India.

Abstract

Background:

Head-and-neck soft-tissue sarcomas (HNSTS) are extremely rare and lack definite guidelines.

Methods:

We retrospectively analyzed consecutive adult patients with HNSTS who presented to our sarcoma medical oncology clinic from January 2016 to October 2017.

Results:

There were a total of 30 patients. Unresectable localized disease was seen in 13 (43%) patients, metastatic disease 10 (34%) patients, while resectable disease in 7 (23%) patients only. Among unresectable localized disease, 3 (25%) patients could be converted to resectable disease after neoadjuvant therapy. Median follow period was 11 months. Progression-free survival was 19 months in patients with resectable disease and 6 months in patients with the unresectable/metastatic disease. Median OS was not reached.

Conclusion:

Unresectable HNSTS has a poor outcome. Neoadjuvant therapy can be tried in selected cases for achieving respectability or for vital organ preservation until robust data are available. A multidisciplinary approach for local control is crucial in managing unresectable HNSTS.

KEYWORDS:

Head-and-neck sarcoma; multimodality treatment; neoadjuvant therapy; soft-tissue sarcoma; unresectable

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