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South Asian J Cancer. 2019 Jan-Mar;8(1):31-34. doi: 10.4103/sajc.sajc_205_17.

Transarterial radioembolization with Iodine-131-Lipiodol for hepatic metastases from gastrointestinal malignancies - Experience in tertiary care oncology center in India.

Author information

Department of Interventional Radiology, Health Care Global Hospitals, Bengaluru, Karnataka, India.
Department of Nuclear Medicine, Health Care Global Hospitals, Bengaluru, Karnataka, India.
Department of Radiology, Shalby Hospitals, Ahmedabad, Gujarat, India.
Department of Medical Oncology, Health Care Global Hospitals, Bengaluru, Karnataka, India.



Unresectable colorectal hepatic metastases can be treated with radioembolization.


The aim of this study is to analyze the response and survival benefits of transarterial radioembolization (TARE) with Iodine-131 (131I) Lipiodol for hepatic metastases from gastrointestinal malignancies.

Settings and Design:

Retrospective study of 20 patients with pathologically proven hepatic metastases from primary gastrointestinal malignancies referred for palliative therapy with TARE.

Subjects and Methods:

At baseline, standard laboratory and imaging data were recorded. All patients fulfilling the inclusion/exclusion criteria underwent TARE with 131I Lipiodol. Post procedure, the patients were reviewed after 1 month with follow-up positron emission tomography-computed tomography and tumor marker levels to evaluate treatment response with continued follow-up till December 2016 and overall survival calculated.

Statistical Analysis Used:

Data were analyzed using a statistical analysis package (Social sciences, version 15.0 for Windows; SSPS Inc.). Survival data were plotted using Kaplan-Meier survival curves.


At the end of follow-up period, 15 of 20 patients were alive. The mean and median survival was 38.88 ± 5.0 months (95% confidence interval [CI], 29.03-48.74 months, P = 0.17) and 49.3 ± 12.4 months (95% CI, 25.0-73.7 months, P = 0.17), respectively. 66 months survival was 75%. Response evaluation in 10 patients showed partial response in 3 (30%), stable disease in 2 (20%) and progressive disease in 5 (50%) patients. All patients with partial response showed a reduction in serum tumor marker levels.


TARE with 131I-Lipiodol is highly effective with a significant survival benefit in refractory cases of hepatic metastases from gastrointestinal malignancies.


Iodine-131-Lipiodol; hepatic metastases; transarterial radioembolization

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