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Prz Menopauzalny. 2018 Dec;17(4):155-160. doi: 10.5114/pm.2018.81737. Epub 2018 Dec 30.

Effects of six weeks of resistance-endurance training on microRNA-29 expression in the heart of ovariectomised rats.

Author information

1
Department of Physical Education and Sports Science, Shabestar Branch, Islamic Azad University, Iran.
2
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
3
Department of Health and Kinesiology, Texas A&M University, College Station, Texas, United States.
4
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Aras International Campus, Tehran, Iran.
5
School of Sport, Exercise, and Nutrition, Massey University, Palmerston North, New Zealand.
6
Nutrition and Physical Activity Laboratory, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
7
Department of Biological Sciences, Faculty of Life Sciences, University Andres Bello, Santiago, Chile.

Abstract

Introduction:

Heart disease risk rises with age. However, women's symptoms become more pronounced following the onset of menopause. The aim of the present study was to evaluate the effects of six weeks of combined resistance-endurance (RE) training on microRNA-29 expression in the heart of ovariectomised rats.

Material and methods:

Thirty female Wistar rats were divided into three groups: 1) sham (SHAM); 2) ovariectomy (OVX); and 3) OVX with RE training (OVX + RE). The effects of these treatments on cardiac microRNA-29 expression were measured using real-time PCR. Data were analysed using a 2 × 3 ANOVA and Tukey post-hoc comparisons and presented as mean ±SEM.

Results:

Ovariectomy resulted in a significant down-regulation in the heart microRNA-29 gene expression of OVX (0.265 ±0.031 fold changes), OVX + RE (0.699 ±0.038 fold changes) in animals vs. sham animals (1 ±0 fold changes; all, p < 0.05) following six weeks of treatment. However, microRNA-29 expression in the OVX + RE group was significantly greater than in the OVX group (p < 0.05).

Conclusions:

Our findings suggest that the six weeks of regular RE training attenuate the reduction in heart muscle microRNA-29 expression observed in ovariectomised rates. If our findings carry over to humans, such an exercise regimen could be beneficial to the cardiovascular disease risk in women during menopause.

KEYWORDS:

cardiac; exercise training; microRNA-29; ovariectomy

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