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Gan To Kagaku Ryoho. 2019 Jan;46(1):109-111.

[Investigation of Colorectal Cancer Cases among Patients Aged over 75 Years Who Received Postoperative Adjuvant Chemotherapy].

[Article in Japanese]

Author information

1
Dept. of Surgery, JCHO Sapporo Hokushin Medical Hospital.

Abstract

BACKGROUND:

As the aging of the Japanese population progresses, the administration of postoperative adjuvant chemotherapy( AC)to the elderly is also expected to increase.

OBJECTIVE:

To examine the characteristics of AC in cases of colorectal cancer among elderly people aged over 75 years.

PATIENTS:

Forty-eight cases of colorectal cancer patients who received AC.

METHODS:

The clinicopathological factors, including 14 patient-related factors, 6 operation-related factors, and 2 AC-related factors, as well as the long-term outcomes, were compared between the elderly group of patients aged over 75 years(group O, 12 cases)and the non-elderly group(group Y, 36 cases).

RESULTS:

Significant differences were observed between groups in neutrophil count(p=0.044), operation time(p=0.044), AC regimen(p=0.006), and administration completion status (p=0.046). Compared to group Y, a higher proportion of oral drug alone(92% vs 39%)and completion rate of the initial setting dose(75% vs 39%)were observed in group O. There was no significant difference in the 2-year disease-free survival rate.

CONCLUSION:

Oral preparations of AC may be useful from the viewpoint of tolerability in the elderly.

PMID:
30765657

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