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Cell Host Microbe. 2019 Feb 13;25(2):175-176. doi: 10.1016/j.chom.2019.01.012.

Sugar and Fatty Acids Ack-celerate Prophage Induction.

Author information

1
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
2
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: breck.duerkop@ucdenver.edu.

Abstract

Intestinal cues driving prophage induction in the microbiota are largely unknown. In this issue of Cell Host & Microbe, Oh et al. (2018) reveal that dietary fructose- and microbiota-derived short-chain fatty acids promote AckA-mediated acetic acid biosynthesis, triggering a stress response that facilities phage production.

PMID:
30763529
PMCID:
PMC6428061
DOI:
10.1016/j.chom.2019.01.012
[Indexed for MEDLINE]
Free PMC Article

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