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Circ Res. 2019 Feb 15;124(4):619-630. doi: 10.1161/CIRCRESAHA.118.312438.

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm.

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From the Wallace H. Coulter Department of Biomedical Engineering, Emory University, Georgia Institute of Technology, Atlanta (S.K., H.J.).
Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, Frankfurt, Germany (R.A.B., S.D.).
Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands (R.A.B.).
German Center of Cardiovascular Research DZHK, Frankfurt, Germany (R.A.B., S.D.).
Department of Medicine, Karolinska Institute, Stockholm, Sweden (L.M.).
Department of Vascular and Endovascular Surgery, Technical University Munich, Germany (L.M.).
German Center for Cardiovascular Research DZHK, Munich, Germany (L.M.).
Division of Cardiology, Emory University, Atlanta, GA (H.J.).


Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall and is among the most challenging cardiovascular diseases as without urgent surgical intervention, ruptured AAA has a mortality rate of >80%. Most patients present acutely after aneurysm rupture or dissection from a previously asymptomatic condition and are managed by either surgery or endovascular repair. Patients usually are old and have other concurrent diseases and conditions, such as diabetes mellitus, obesity, and hypercholesterolemia making surgical intervention more difficult. Collectively, these issues have driven the search for alternative methods of diagnosing, monitoring, and treating AAA using therapeutics and less invasive approaches. Noncoding RNAs-short noncoding RNAs (microRNAs) and long-noncoding RNAs-are emerging as new fundamental regulators of gene expression. Researchers and clinicians are aiming at targeting these microRNAs and long noncoding RNAs and exploit their potential as clinical biomarkers and new therapeutic targets for AAAs. While the role of miRNAs in AAA is established, studies on long-noncoding RNAs are only beginning to emerge, suggesting their important yet unexplored role in vascular physiology and disease. Here, we review the role of noncoding RNAs and their target genes focusing on their role in AAA. We also discuss the animal models used for mechanistic understanding of AAA. Furthermore, we discuss the potential role of microRNAs and long noncoding RNAs as clinical biomarkers and therapeutics.


aortic aneurysms; biomarkers; dissection; long noncoding RNA; microRNAs

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