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ACS Appl Mater Interfaces. 2019 Mar 6;11(9):8831-8837. doi: 10.1021/acsami.8b21199. Epub 2019 Feb 25.

T98G Cell Death Induced by Photothermal Treatment with Hollow Gold Nanoshell-Coupled Silica Microrods Prepared from Escherichia Coli.

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Department of Chemical Engineering , Kwangwoon University , 20 Kwangwoon-ro , Nowon-gu, Seoul 01897 , Korea.
Graduate School of East-West Medical Science , Kyung Hee University , Yongin 17104 , Korea.


As an alternative to traditional cancer treatment, photothermal therapy is a promising method with advantages such as noninvasiveness and high efficiency. Herein, we synthesized armored golden Escherichia coli (AGE) microrods as photothermal agents to evaluate the viability of cancer cell. The hollow gold nanoshell (HAuNS) was synthesized for photothermal effects under the near-infrared (NIR) region using unicellular E. coli as a framework. Coupling HAuNS onto the surface of E. coli@SiO2 enhanced temperature elevation and resulted in high conversion efficiency. The synthesized AGE microrods had excellent photothermal stability under NIR laser irradiation in the five-times recycling experiment. The temperature elevation of AGE microrod solution reached 43.7 °C, which induced hyperthermia-mediated killing of tumor cells. The results of the cytotoxicity test revealed the AGE microrod-induced T98G cell death mediated via apoptosis.


Escherichia coli; T98G cell; hollow gold nanoshell; near-infrared irradiation; photothermal treatment; tumor cell

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