Format

Send to

Choose Destination
J Clin Periodontol. 2019 Feb 14. doi: 10.1111/jcpe.13087. [Epub ahead of print]

Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study.

Author information

1
Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
2
Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
3
Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, Germany.
4
Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Berlin, Germany.
5
Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt.
6
Cluster of Excellence, Inflammation at Interfaces, Christian-Albrechts-University Kiel, Kiel, Germany.

Abstract

AIM:

Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach.

MATERIALS AND METHODS:

sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. A total of 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design.

RESULTS:

Systemic sFRP5 serum levels were significantly lower in patients with periodontitis and tooth loss (2.5 [0.0-10.4] ng/ml, median [IQR]) compared to patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR], p = 0.04] and matched controls (7.0 [2.5-18.3] ng/ml, median [IQR], p = 0.02). No significant differences in sFRP5 serum levels were found among patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR]) and controls (3.1 [0.0-10.6] ng/ml, median [IQR], p = 0.06).

CONCLUSIONS:

sFRP5 might serve as a novel biomarker for periodontitis severity. Modulating the inflammatory background of severe forms of periodontitis, in the time of precision medicine, needs to be revealed in further studies.

KEYWORDS:

biomarkers; inflammation; metabolism; periodontitis; pharmacological; sFRP5; wnt5a

PMID:
30762911
DOI:
10.1111/jcpe.13087

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center